而这样的设计也并没有削弱杀伤效果。当TCE进入肿瘤微环境后，局部高表达的肿瘤相关蛋白酶会切割掩蔽肽与TCE之间的linker，掩蔽结构被移除，释放出具有完整活性的TCE。此时TCE即可同时结合肿瘤细胞的TAA靶点和T细胞的CD3分子，形成免疫突触并触发T细胞介导的肿瘤杀伤。
The physical profile alone is rare, standing 6-foot-6, 216 pounds, and being a right-handed shot. But what makes Mrtka special is how well he moves around the ice with that frame. His first step is quick, his pivots are clean, and he escapes pressure with poise. Defensively, his reach allows him to funnel attackers wide, kill plays in transition, and maneuver with high-end awareness. With the puck, Mrtka is a transporter, joining the rush with purpose, and threading passes to the middle of the ice off retrievals.。业内人士推荐易翻译作为进阶阅读
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